Data/hora: 06/06/2024 00:38:04

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation	
Autores: 	Ben J. C. Quah; Vaughan  P. Barlow; Virginia McPhun; Klaus   I. Matthaei; Mark  D. Hulett; Christopher   R. Parish.	
Data: 	2007-10-05	
Ano: 	2007	
Palavras-chave: 	Immunology.	
Resumo: 	The B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1). Despite this, the majority of B cells are only thought to play a limited role in CD4+ T cell activation since BCRs are clonotypically expressed. Here we show, however, that activated B cells can, both in vitro and in vivo, rapidly donate their BCR to bystander B cells, a process that is mediated by direct membrane transfer between adjacent B cells and is amplified by the interaction of the BCR with specific antigen. This results in a dramatic expansion in the number of antigen-binding B cells in vivo, with the transferred BCR endowing recipient B cells with the ability to present specific antigen to antigen-specific CD4+ T cells.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/1207/version/1

oai:nature.com:10.1038/npre.2007.1207.1

http://dx.doi.org/10.1038/npre.2007.1207.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License