Data/hora: 11/06/2024 12:22:13

Provedor de dados: | 17
País: | United Kingdom
Título: | Parkinson&amp;#x2019;s disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein
Autores: | Wanchung(Wanjiung) Hu.
Data: | 2011-08-02
Ano: | 2011
Palavras-chave: | Genetics &amp; Genomics; Immunology; Neuroscience; Bioinformatics.
Resumo: | Parkinson&amp;#x2019;s disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson&amp;#x2019;s disease is still unknown, so it is called idiopathic Parkinsonism. According to my microarray analysis of peripheral blood leukocytes and substantia nigra brain tissue, I propose that Parkinson&amp;#x2019;s disease is actually a TH17 dominant autoimmune disease. The autoantigen is mainly alpha-synuclein. After knowing the exact disease pathophysiology, we can develop better drugs to prevent or control the detrimental disorder.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/6176/version/1

oai:nature.com:10101/npre.2011.6176.1

http://hdl.handle.net/10101/npre.2011.6176.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License