Data/hora: 01/06/2024 02:13:28

Provedor de dados: | 17
País: | United Kingdom
Título: | 11[beta]-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17[beta]-hydroxysteroid dehydrogenase-type 2
Autores: | Michael E. Baker.
Data: | 2010-07-10
Ano: | 2010
Palavras-chave: | Cancer; Developmental Biology; Pharmacology; Bioinformatics; Evolutionary Biology.
Resumo: | 11[beta]-hydroxysteroid dehydrogenase type-2 (11[beta]-HSD2) regulates the local concentration of cortisol that can activate the glucocorticoid receptor and mineralocorticoid receptor, as well as the concentration of 11-keto-testosterone, the active androgen in fish.  Similarly, 17[beta]-HSD2 regulates the levels of testosterone and estradiol that activate the androgen receptor and estrogen receptor, respectively.  Interestingly, although human 11[beta]-HSD2 and 17[beta]-HSD2 act at different positions on different steroids, these enzymes are paralogs.  Despite the physiological importance of 11[beta]-HSD2 and 17[beta]-HSD2, details of their origins and divergence from a common ancestor are not known.  An opportunity to understand their evolution is presented by the recent sequencing of genomes from sea urchin, a basal deuterostome, and amphioxus, a basal chordate, and the availability of substantial sequence for acorn worm and elephant shark, which together provide a more complete dataset for analysis of the origins of 11[beta]-HSD2 and 17[beta]-HSD2.  BLAST searches find an ancestral sequence of 17[beta]-HSD2 in sea urchin, acorn worm and amphioxus, while an ancestral sequence of 11[beta]-HSD2 first appears in sharks.  Sequence analyses indicate that 17[beta]-HSD2 in sea urchin may have a non-enzymatic activity.  Evolutionary analyses indicate that if acorn worm 17[beta]-HSD2 is catalytically active, then it metabolizes novel substrate(s).
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/4649/version/1

oai:nature.com:10.1038/npre.2010.4649.1

http://dx.doi.org/10.1038/npre.2010.4649.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License