Data/hora: 06/06/2024 01:25:41

Provedor de dados: | 17
País: | United Kingdom
Título: | Successful use of axonal transport for drug delivery by synthetic molecular vehicles
Autores: | Aaron G. Filler; Garth Whiteside; Mark Bacon; Martyn Frederickson; Franklyn A. Howe; Miri K. Rabinowitz; Alan J. Sokoloff; Terrence Deacon; Chris Abell; Raj Munglani; John R. Griffiths; B. Anthony Bell; Andrew Lever.
Data: | 2008-08-06
Ano: | 2008
Palavras-chave: | Biotechnology; Chemistry; Molecular Cell Biology; Neuroscience; Pharmacology.
Resumo: | We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules. The complex efficiently enters nerve terminals after intramuscular or intradermal administration and travels within axonal processes to neuron cell bodies. The tripartite agent provided 100-fold amplification of saturable neural uptake events, delivering multiple drug molecules per complex. _In vivo_, analgesic drug delivery to systemic and to non-targeted neural tissues was greatly reduced compared to existing routes of administration, thus exemplifying the possibility of specific nerve root targeting and effectively increasing the potency of the candidate drug gabapentin 300-fold relative to oral administration.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/2164/version/1

oai:nature.com:10101/npre.2008.2164.1

http://hdl.handle.net/10101/npre.2008.2164.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License