Data/hora: 05/06/2024 17:09:58

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	CD14 Modulates PI3K/AKT/p38-MAPK Licensing of Negative Regulators of TLR Signaling to Restrain Chronic Inflammation	
Autores: 	Bikash Sahay; Rebeca L. Patsey; Nicole Whatley; Sasmita Nayak; Christian H. Eggers; Justin D. Radolf; Timothy J. Sellati.	
Data: 	2008-06-24	
Ano: 	2008	
Palavras-chave: 	Immunology; Microbiology.	
Resumo: 	Current thinking emphasizes the primacy of CD14 in facilitating TLR recognition of microbes to initiate proinflammatory signaling events and the importance of p38-MAPK in augmenting such responses. Herein, this paradigm is challenged by demonstrating that recognition of _Borrelia burgdorferi_ not only triggers an inflammatory response in the absence of CD14, but one that is uncontrolled as a consequence of impaired PI3K/AKT/p38-MAPK signaling and negative regulation of TLR2. CD14 deficiency results in hyperphosphorylation of AKT and reduced activation of p38. Such aberrant signaling leads to decreased negative regulation by SOCS1, SOCS3, and CIS thereby engendering a more severe and persistent inflammatory response to _B. burgdorferi_. Perturbation of this CD14/p38-MAPK-dependent mechanism of immune regulation may underlie development of infectious chronic inflammatory syndromes.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/2005/version/1

oai:nature.com:10101/npre.2008.2005.1

http://hdl.handle.net/10101/npre.2008.2005.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License