Data/hora: 11/06/2024 07:16:01

Provedor de dados: | 17
País: | United Kingdom
Título: | A dynamical model of genetic networks describes cell differentiation
Autores: | Roberto Serra; Villani Marco; Alessia Barbieri.
Data: | 2010-08-05
Ano: | 2010
Palavras-chave: | Molecular Cell Biology; Bioinformatics.
Resumo: | Cell differentiation is a complex phenomenon whereby a stem cell becomes progressively more specialized and eventually gives rise to a specific cell type. Differentiation can be either stochastic or, when appropriate signals are present, it can be driven to take a specific route. Induced pluripotency has also been recently obtained by overexpressing some genes in a differentiated cell. Here we show that a stochastic dynamical model of genetic networks can satisfactorily describe all these important features of differentiation, and others. The model is based on the emergent properties of generic genetic networks, it does not refer to specific control circuits and it can therefore hold for a wide class of lineages. The model points to a peculiar role of cellular noise in differentiation, which has never been hypothesized so far, and leads to non trivial predictions which could be subject to experimental testing.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/4741/version/1

oai:nature.com:10101/npre.2010.4741.1

http://hdl.handle.net/10101/npre.2010.4741.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License