Data/hora: 05/06/2024 14:40:55

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Swine Influenza A Evolution via Recombination - Genetic Drift Reservoir	
Autores: 	Henry L. Niman.	
Data: 	2007-07-07	
Ano: 	2007	
Palavras-chave: 	Ecology; Genetics &amp; Genomics.	
Resumo: 	The looming influenza pandemic has focused attention^1-4^ on the rapid evolution of H5N1 and other human and avian serotypes.  The basic tenets of influenza genetics^5^ define gradual changes as drifts caused by point mutations created by a polymerase that lacks a proof reading function.  More abrupt changes have been linked to reassortment, which shuffles the eight sub-genomic segments of the influenza genome in dually infected host. The complex evolution of these viruses has created a challenge in vaccine development.  Swine influenza isolates from 2003 and 2004 have been identified^6^ that have acquired a human influenza gene, PB1.  My analysis of the eight gene segments found large portions of two genes, PB2 and PA, which were identical matches with 1977 swine isolates^7,8^.  Additional regions were exact matches with 1998 and 2002 isolates,^9,10^ demonstrating homologous recombination between earlier genomes.  The absolute fidelity discounts the role of point mutations in gene drift. Moreover the human PB1 gene represented a reservoir for acquisition of polymorphisms in human seasonal flu.  These observations challenge the basic tenets of influenza genetics and provide a method for predicting the changes in seasonal and pandemic influenza, as well as other rapidly evolving genomes.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/385/version/1

oai:nature.com:10101/npre.2007.385.1

http://hdl.handle.net/10101/npre.2007.385.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License