Data/hora: 01/06/2024 00:32:40

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	A new functional role for lateral inhibition in the striatum: Pavlovian conditioning	
Autores: 	Patrick Connor; Thomas Trappenberg.	
Data: 	2011-05-31	
Ano: 	2011	
Palavras-chave: 	Neuroscience.	
Resumo: 	The striatum has long been implicated in reinforcement learning and has been suggested by several neurophysiological studies as the substrate for encoding the reward value of stimuli. Reward prediction error (RPE) has been used in several basal ganglia models as the underlying learning signal, which leads to Pavlovian conditioning abilities that can be simulated by the Rescorla-Wagner model.&amp;#xd;&amp;#xa;&amp;#xd;&amp;#xa;Lateral inhibition between striatal projection neurons was once thought to have a winner-take-all function, useful in selecting between possible actions. However, it has been noted that the necessary reciprocal connections for this interpretation are too few, and the relative strength of these synaptic connections is weak. Still, modeling studies show that lateral inhibition does have an overall suppression effect on striatal activity and may play an important role in striatal  processing. &amp;#xd;&amp;#xa;&amp;#xd;&amp;#xa;Neurophysiological recordings show task-relevant ensembles of responsive neurons at specific points in a behavioral paradigm (Barnes et al., 2005), which appear to be induced by lateral inhibition (see Ponzi and Wickens, 2010). We have developed a similarly responding, RPE-based model of the striatum by incorporating lateral inhibition. Model neurons are assigned to either the direct or the indirect pathway but lateral connections occur within and between these groups, leading to competition between both the individual neurons and their pathways.  We successfully applied this model to the simulation of Pavlovian phenomena beyond those of the Rescorla-Wagner model, including negative patterning, unovershadowing, and external inhibition.	
Tipo: 	Poster	
Identificador: 	http://precedings.nature.com/documents/5986/version/1

oai:nature.com:10.1038/npre.2011.5986.1

http://dx.doi.org/10.1038/npre.2011.5986.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License