Data/hora: 11/06/2024 03:56:30

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Biomimetic assemblage of nucleobase 5-fluorouracil into nano-size three-dimensional particles	
Autores: 	Arun Chauhan; Swaleha Zubair; Qamar Zia; Saba Tufail; Asif Sherwani; Mohammad Sajid; Mohammad Owais.	
Data: 	2011-08-03	
Ano: 	2011	
Palavras-chave: 	Biotechnology; Cancer; Chemistry; Molecular Cell Biology.	
Resumo: 	Biomimetic nano-assembly formation offers a convenient and bio friendly approach to fabricate complex structures from simple components with sub-nanometer precision. Recently, extract from cells of microorganism/plant origin have emerged as a simple and viable route for the synthesis of metal and inorganic material nano-particles. In the present study, we have extended biological synthesis of nano-particles to organic molecules, namely the anticancer agent, 5-fluorouracil (5-FU) using Aloe vera leaf extract. The formation of 5-FU nano- particles was assessed by UV, FT-IR and fluorescence spectroscopic techniques. Transmission electron microscopy and atomic force microscopic techniques confirmed nano-size of the synthesized particles. Importantly, the nano-assembled 5-FU retained its anticancer action against various cancer cell lines. Finally, the anti-tumor potential of 5-FU nano-particles was established against DMBA induced fibrosarcoma in Balb/c mice.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/6182/version/1

oai:nature.com:10101/npre.2011.6182.1

http://hdl.handle.net/10101/npre.2011.6182.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License