Data/hora: 06/06/2024 01:17:11

Provedor de dados: | 17
País: | United Kingdom
Título: | Genome activity profiling of monomeric-IgE and Fc-epsilon-RI-aggregation on human mast cells reveals a complex network of genes involved in inflammatory responses.
Autores: | Jayapal J. Manikandan; Alirio Jose P. N. Melendez; Peter Natesan A. J. Pushparaj.
Data: | 2007-09-27
Ano: | 2007
Palavras-chave: | Immunology; Molecular Cell Biology; Pharmacology; Bioinformatics.
Resumo: | Mast cell activation, mediates type-1 allergic responses, one of the most powerful reactions of the immune system. However, mast cells activation is becoming increasingly linked to inflammatory, autoimmunity, and to adaptive immunity by regulating T-cell activation.&amp;#xd;&amp;#xa;Here we analyzed the gene expression pattern in IgE-sensitized and Fc&amp;#x3b5;RI aggregation on human mast cells. Our data revealed coordinated changes in gene expression. We observed increased expression of gene-transcripts involved in allergic, innate and adaptive&amp;#xd;&amp;#xa;immune responses. Among the most prominent findings is the increased expression of transcripts encoding for MIP3a, SPARCL1, AREG, IL18, CCL1, TNFRSF9, IL1b, CX3CR1, PTGER3, MIF, MMP12, ADORA3, IL8RB, and other genes involved in innate and cellmediated&amp;#xd;&amp;#xa;immunity. These results represent a substantial advance in our understanding of the genome-wide effects triggered by &amp;#x201c;passive sensitization&amp;#x201d; or active stimulation of human mast cells, and how this relate to mast cells involvement not only in allergic&amp;#xd;&amp;#xa;responses but also in innate and adaptive immunity.
Tipo: | Poster

Identificador:

http://precedings.nature.com/documents/1150/version/1

oai:nature.com:10.1038/npre.2007.1150.1

http://dx.doi.org/10.1038/npre.2007.1150.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License