Data/hora: 16/06/2024 03:46:01

Provedor de dados: 	17	
País: 	United Kingdom	
Título: 	Trypsin digest of cancer cells surface stimulates anti-tumor immune response better than cancer cells themselves	
Autores: 	Petr Lokhov; Balashova Elena.	
Data: 	2010-09-13	
Ano: 	2010	
Palavras-chave: 	Biotechnology; Cancer; Immunology.	
Resumo: 	Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development. Treating surface of live human breast adenocarcinoma cells (MCF-7) with trypsin yields a digest that contains 0.7% of total cell protein. Despite this difference, the trypsin digest stimulates in cytotoxicity assays anti-tumor response which kills 10-40% more cancer cells than those stimulated with cells themselves. From these results, we concluded that trypsin digest obtained from live cancer cells contains the essential antigens to induce an immune-mediated anti-tumor effect, and therefore, is candidate for anti-tumor vaccine development.	
Tipo: 	Manuscript	
Identificador: 	http://precedings.nature.com/documents/4895/version/1

oai:nature.com:10.1038/npre.2010.4895.1

http://dx.doi.org/10.1038/npre.2010.4895.1	
Fonte: 	Nature Precedings	
Fonte: 	Creative Commons Attribution 3.0 License