Data/hora: 11/06/2024 04:27:58

Provedor de dados: | 19
País: | Japan
Título: | The epidemiological survey for atovaquone resistant related gene of Babesia gibsoni in Japan
Autores: | Iguchi, Aiko; Soma, Takehisa; Suzuki, Hiroshi; Xuan, Xuenan.
Data: | 2016-03
Ano: | 2016
Palavras-chave: | Allele-specific real-time PCR; Babesia gibsoni; Drug resistance; M121I variant population.
Resumo: | In 73 gDNA samples from Babesia gibsoni-infected dogs, the M121I variant population was measured by using allele-specific real-time PCR. Although the mechanism of atovaquone against B. gibsoni has not been clearly identified, it is reported that the mitochondria cytochrome b gene of the atovaquone-resistant B. gibsoni had a single-nucleotide substitution at nt363 (G to T), which resulted in the substitution of methionine with isoleucine (M121I). In this study, 3/73 samples showed over 5% M121I variant population. Although the M121I variant population is a low percentage, it runs the risk of spreading drug-resistant parasites. It is important to prevent the spread of drug-resistance, so we need to gather information about this at regular intervals.
Idioma: | Inglês

Identificador:

http://ir.obihiro.ac.jp/dspace/handle/10322/4421

info:doi/10.1292/jvms.15-0480

Editor: | Japanese Society of Veterinary Science
Fonte: | This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License &lt;http://creativecommons.org/licenses/by-nc-nd/4.0/&gt;.