Data/hora: 05/06/2024 17:18:17

Provedor de dados: | 19
País: | Japan
Título: | Effects of Orally Administrated Mosapride, a 5-HT4 Receptor Agonist on the Digestive Tract of Horses
Autores: | SASAKI, Naoki; LEE, Inhyung; AYUKAWA, Yu; YAMADA, Haruo; 佐々木, 直樹.
Data: | 2004
Ano: | 2004
Palavras-chave: | Equine; Gastrokinetic agent; Mosapride; Oral administration; 5-HT4 receptor agonist.
Resumo: | The effects of mosapride, a 5-hydroxytryptamine 4 (5-HT4) receptor agonist, on the motility of horse small intestine were examined by means of electrointestinography (EIG). Six adult healthy thoroughbreds were used, in which EIG signals from the small intestine were measured by a Degetorappar EGG system. Mosapride, dissolved in 200 ml water, was orally administered at a dose of 2 mg/kg. The total power of EIG signals at a frequency band of 3 cpm was 419.1 ± 122.0 (μV) 2 × cpm (n=6) before, and 2,093.6 ± 850.0 (μV)2 × cpm (n=6) after the drug administration, the latter mean value being significantly greater than the former. This result suggests that mosapride has a prokinetic action on the motility of horse small intestine.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/3100
Editor: | 日本ウマ科学会
Formato: | application/pdf
Fonte: | 日本ウマ科学会