Data/hora: 02/06/2024 13:12:36

Provedor de dados: 	19	
País: 	Japan	
Título: 	Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes	
Autores: 	Han, Kyu-Ho; Hashimoto, Naoto; Fukushima, Michihiro.	
Data: 	2016-01-07	
Ano: 	2016	
Palavras-chave: 	Electrophile; Mitogen-activating protein kinase; Plant antioxidants; Reactive oxygen species; Preconditioning.	
Resumo: 	Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide. The meta-bolism of ethanol generates reactive oxygen species, which play a significant role in the deterioration of alcoholic liver disease (ALD). Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase. These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelchlike ECH-associated protein 1-NF-E2-related factor-2 pathway and antioxidant responsive elements. Furthermore, these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines. These phenomena are likely induced via the regulation of mitogen-activating protein kinase (MAPK) pathways by plant antioxidants, similar to preconditioning in ischemia-reperfusion models. Although the relationship between plant antioxidants and ALD has not been adequately investigated, plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway.	
Idioma: 	Inglês	
Identificador: 	http://ir.obihiro.ac.jp/dspace/handle/10322/4425

info:doi/10.3748/wjg.v22.i1.37	
Editor: 	Baishideng Publishing Group	
Fonte: 	This is an open access article licensed under the terms of the Creative Commons Attribution (by) License. &lt;http://creativecommons.org/lisenses/by/4.0/&gt;