Data/hora: 06/06/2024 03:28:05

Provedor de dados: | 19
País: | Japan

Título:

20-Methylcholanthrene誘発腫瘍担癌マウスに対するトキソプラズマ溶解抗原の治療的投与効果

Therapeutic Effects of Toxoplasma Lysate Antigen on 20-Methylcholanthrene-Induced BALB/c Mouse Tumors

Autores: | 宮原, 和郎; 本多, 字里子; 戸瀬, 信一; 櫻井, 治久; 五十嵐, 郁男; 齋藤, 篤志; 広瀬, 恒夫; 鈴木, 直義; MIYAHARA, Kazuro.
Data: | 1992
Ano: | 1992
Palavras-chave: | Methylcholanthrene-induced tumor; Mouse spleen cell therapeutic effect Toxoplasma lysate antigen.
Resumo: | Therapeutic effects of Toxoplasma lysate antigen (TLA) were studied in mice bearing the tumor in the second passage of 20-methylcholanthrene (MC)-induced tumor cells. Intramuscular administration of TLA 7 days after the tumor-cell inoculation caused apparent inhibition of the tumor growth on day 14. The second treatment facilitated the therapeutic effects. Intravenous transfer of spleen cells prepared from TLA-sensitized mice into tumor-bearing mice also represented the growth inhibitory effects. Prominent effects were seen when the transferred cells were prepared 5 days after sensitization of donor animals. The inhibitory effects were absent in the groups transferred only the adherent cells or the non-adherent cells prepared from sensitized mice. The strongest inhibitory effect was observed in the group to which both adherent and non-adherent spleen cells were transferred simultaneously from sensitized mice. In in vitro experiments, spleen cells obtained from sensitized mice showed cytolytic effect on P-815 or YAC-1 cells after the secondary stimulation in vitro with TLA. Large non-adherent cells containing densely packed granules were induced when cultured with the adherent cells obtained from sensitized mice. These results revealed that TLA can inhibit the growth of the chemically-induced transplantable tumors by activation of adherent and non-adherent spleen cells.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/4062
Editor: | 日本獣医学会
Fonte: | 日本獣医学会