Data/hora: 11/06/2024 11:00:31

Provedor de dados: 	19	
País: 	Japan	
Título: 	Sialyl Oligosaccharides in the Milk of Japanese Women: Changes in Concentration during the Course of Lactation

日本人女性の乳中に含まれるシアリルオリゴ糖の泌乳期における経時的変動	
Autores: 	Sumiyoshi, Wataru; Urashima, Tadasu; Nakamura, Tadashi; Arai, Ikichi; Nagasawa, Takashi; Saito, Tadao; Tsumura, Norihiko; Wang, Bing; Brand-Miller, Janette; Watanabe, Yoko; Kimura, Kazumasa; 住吉, 渉; 浦島, 匡; 中村, 正; 荒井, 威吉; 長澤, 孝志; 齋藤, 忠夫; 津村, 宣彦; 渡邉, 陽子; 木村, 一雅.	
Data: 	2003	
Ano: 	2003	
Palavras-chave: 	Human milk; Sialyl oligosaccharide; Lactation period; PMP; Reverse phase HPLC.	
Resumo: 	The concentrations of the six major sialyl oligosaccharides found in the milk of 24 Japanese women were determined using reverse phase high performance liquid chromatography of the 3-methyl-1-phenyl-5- pyrazolone derivatives of the oligosaccharides. The milk was collected at 4, 10, 30 and 100 days postpartum. The concentrations of all six oligosaccharides decreased during the course of lactation. The concentrations of 6'-sialyllactose, sialyllacto-N-tetraose b and disialyllacto-N-tetraose decreased only after 10 days postpartum, whereas those of sialyllacto-N-tetraose a and sialyllacto-N-neotetraose c as well as 3'-sialyllactose decreased from 4 days postpartum. Large differences were observed between present data and those previously reported for Italian women, both in terms of the content and in the variation pattern of each oligosaccharide during the course of lactation. These differences may be caused by the different ethnicity of the donors as well as the assay methods used in the studies.  日本人女性の乳中に含まれる6種のシアリルオリゴ糖濃度の泌乳期に伴う変動を,PMP誘導体化を用いた逆相HPLCにより定量した.DSLNT,6ノーSLおよびLSTb濃度は出産後10日目までの変化は少なく,それ以降減少したが,LSTc,LSTaおよび3'-SL濃度は出産後4日目から100日目まで減少し続けた.本研究と以前に報告されたイタリア人女性の乳でのデータでは,泌乳期の経過に伴う各オリゴ糖の濃度およびその変動パターンに大きな差が見られた.これらの差はドナーの人種差によるばかりではなく,両者の定量方法の違いによっても生じたものと考えられる.また,本研究と以前に報告された日本人女性の乳中における3'-SLおよび6'-SLの定量データとは,泌乳期による変動パターンが類似していた.	
Idioma: 	Inglês	
Identificador: 	http://ir.obihiro.ac.jp/dspace/handle/10322/3287	
Editor: 	日本応用糖質科学会	
Formato: 	application/pdf	
Fonte: 	日本応用糖質科学会