Data/hora: 05/06/2024 08:29:55

Provedor de dados: | 19
País: | Japan

Título:

トキソプラズマ溶解抗原(TLA)で誘導されるマウス脾臓内の細胞障害性細胞の性質

Characteristics of Cytotoxic Cells Induced by Toxoplasma Lysate Antigen in Mouse Spleen

Autores: | MIYAHARA, Kazuro; MATSUMOTO, Toru; TOSE, Shinichi; SAKURAI, Haruhisa; IGARASHI, Ikuo; SAITO, Atsushi; HIROSE, Tsuneo; SUZUKI, Naoyoshi; 宮原, 和郎; 五十嵐, 郁男.
Data: | 1992
Ano: | 1992
Palavras-chave: | Cytotoxic activity; Mouse; Phenotype; Spleen cell; Toxoplasma lysate antigen.
Resumo: | Spleen cells from Toxoplasma lysate antigen (TLA)-sensitized BALB/c mice showed the strong cytotoxic activity against both natural killer (NK)-sensitive cells (YAC-1 and RL♂-1) and NK-insensitive cells (P-815), when incubated with TLA or recombinant human IL-2 (rhIL-2). The increment of TLA concentration in culture medium increased the cytotoxic activity. Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity. Treatment of spleen cells from TLA-sensitized mice with anti-asialo GM1 and/or anti-Thy-1 plus complement inhibited cytotoxic activities of effector cells. These results suggested that spleen bells sensitized with TLA both in vivo and in vitro were asialo GM1 positive and Thy-1 positive; and the majority of cytotoxic cells induced by TLA were similar to lymphokine-activated killer (LAK)cells induced by IL-2.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/4063
Editor: | 日本獣医学会
Fonte: | 日本獣医学会