Data/hora: 06/06/2024 15:26:48

Provedor de dados: | 19
País: | Japan
Título: | Changes of splenic interleukin-12p70 concentration in mice infected with Babesia microti and Babesia rodhaini
Autores: | Ohmori, Takashi; Tamahara, Satoshi; Thi, Pham Ngoc; Tomihari, Mizuki; Shimada, Terumasa; Matsuki, Naoaki; Ono, Kenichiro.
Data: | 2005
Ano: | 2005
Palavras-chave: | Babesia microti; Babesia rodhaini; Cell-mediated immunity; Early phase of infection; IL-12p70; Th1 cell differentiation.
Resumo: | Interleukin-12 (IL-12) is one of the most important factors for the host’s protective immune response against protozoan infection. To evaluate the effect of bioactive form of IL-12(IL-12p70), expression of IFN-AmRNA and IL-4 mRNA in splenic CD4 positive T cells, anti-parasite delayed type hypersensitivity (DTH), and serum and splenic IL-12p70 concentration were examined in Babesia microti and B. rodhaini infected mice. The expression of IFN-AmRNA as a marker of Th1 cell differentiation was detected in splenic CD4 positive T cells in B. microti infected mice. Activation of DTH response as a marker of cell-mediated immune response was also observed from 2 days after the infection with B. microti, while no response was detected in B. rodhaini infected mice. Serum IL-12p70 was not detected in both B. microti and B. rodhaini infected mice, however, splenic IL-12p70 concentration increased significantly in B. microti infected mice with peaks at 30 hrs and 4 days after the infection. From these results, splenic IL-12p70 increased at 30 hrs after the B. microti infection was considered to closely relate with Th1 cell differentiation followed by cell-mediated immune response in mice.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/150
Editor: | National Research Center for Protozoan Diseases
Formato: | application/pdf