Data/hora: 02/06/2024 03:48:58

Provedor de dados: | 19
País: | Japan

Título:

Methylcholanthrene自家誘発腫瘍担癌ラットに対するトキソプラズマ溶解抗原の抗腫瘍効果

Antitumor Activity of Toxoplasma Lysate Antigen against Methylcholanthrene-Induced Tumor-Bearing Rats

Autores: | MIYAHARA, Kazuro; YOKOO, Naoya; SAKURAI, Haruhisa; IGARASHI, Ikuo; SAKATA, Yu; YOSHIDA, Yutaka; SAITO, Atsushi; HIROSE, Tsuneo; SUZUKI, Naoyoshi; 宮原, 和郎; 五十嵐, 郁男.
Data: | 1992
Ano: | 1992
Palavras-chave: | Antitumor activity; Methylcholanthrene-autoinduced tumor; Rat; Thy-1 positive granular cell; Toxoplasma lysate antigen.
Resumo: | Growth of the tumor autoinduced by 20-methylcholanthrene (MC) in rats was inhibited after administration of Toxoplasma lysate antigen (TLA). The antitumor activity of TLA was most obvious in the early stage of tumoral growth. When TLA was administered to rats before the appearance of tumor, tumor formation was delayed slightly. Histopathological studies revealed dense growths of spindle tumor cells in untreated control rat, while enlarged central necrosis with the infiltration of lymphocytes and neutrophils was apparent in TLA-treated rats. According to the immunohistological examination of tumor tissue with anti-Thy-1 antibody, the rats treated with TLA showed large Thy-1 positive granular cells, whereas the untreated rats indicated only a few small Thy-1 positive cells. These observations indicate that TLA is a useful modifier of biological responses to MC-induced tumors.
Idioma: | Inglês
Identificador: | http://ir.obihiro.ac.jp/dspace/handle/10322/4064
Editor: | 日本獣医学会
Fonte: | 日本獣医学会