Data/hora: 01/06/2024 05:49:45

Provedor de dados: | 19
País: | Japan
Título: | Babesia bovis: Effects of cysteine protease inhibitors on in vitro growth
Autores: | Okubo, Kazuhiro; Yokoyama, Naoaki; Govind, Yadav; Alhassan, Andy; Igarashi, Ikuo.
Data: | 2007-10
Ano: | 2007
Palavras-chave: | Babesia bovis; Cysteine protease; Inhibitor; Invasion; Replication.
Resumo: | In the present study, we examined the effects of four kinds of cysteine protease inhibitors (E64, E64d, leupeptin, and ALLN) on the in vitro asexual growth of Babesia bovis. Of these, only the lipophilic inhibitors, E64d and ALLN, were found to effectively inhibit the growth of B. bovis. In further experiments, E64d, but not ALLN, significantly suppressed the parasite’s invasion of host erythrocytes, while both chemicals, especially ALLN, inhibited the parasite’s replication within the infected erythrocytes. These data suggested the presence of cysteine protease(s) derived from B. bovis, in which the protease(s) would play important roles in the erythrocyte invasion and/or replication processes of the parasite.
Idioma: | Inglês

Identificador:

http://ir.obihiro.ac.jp/dspace/handle/10322/1041

info:doi/10.1016/j.exppara.2007.04.009

Editor: | Elsevier
Formato: | application/pdf