Data/hora: 09/06/2024 13:25:19

Provedor de dados: 	27	
País: 	Belgium	
Título: 	Drug assimilation in the tissue of European sea bass (&lt;i&gt;Dicentrarchus labrax&lt;/i&gt;) fry delivered orally through bioencapsulation	
Autores: 	Gapasin, R.S.J.; Nelis, H.; Chair, M.; Sorgeloos, P.	
Data: 	1996	
Ano: 	1996	
Palavras-chave: 	Dicentrarchus labrax (Linnaeus; 1758) [Bass].	
Resumo: 	Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (&lt;i&gt;Dicentrarchus labrax&lt;/i&gt;) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in oil emulsion (Selco) at 20% and 40% concentrations (w/w) were bioencapsulated in &lt;i&gt;Artemia&lt;/i&gt; (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentration in the tissue were analysed by high-performance liquid chromatography (HPLC). Fish fed 40% 'medicated' &lt;i&gt;Artemia&lt;/i&gt; assimilated significantly higher levels of chemotherapeutics compared with those fed 20% 'medicated' &lt;i&gt;Artemia&lt;/i&gt; . Chemotherapeutics given at 40% reached peak levels (19.3 µg TMP/g DW and 23.31 µg SMX/g DW) within 2h while those at 20% peaked (8.74 µg TMP/g DW and 6.73 µg SMX/g DW) after 5h. TWP persisted in the tissues longer (up to 72h) than SMX (12-16h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2964	
Relação: 	info:eu-repo/semantics/altIdentifier/wos/A1996UK20900007	
Fonte: 	%3Ci%3EJ.+Appl.+Ichthyol.+12%281%29%3C%2Fi%3E%3A+39-42.+%3Ca+href%3D%22https%3A%2F%2Fhdl.handle.net%2F10.1111%2Fj.1439-0426.1996.tb00057.x%22+target%3D%22_blank%22%3Ehttps%3A%2F%2Fhdl.handle.net%2F10.1111%2Fj.1439-0426.1996.tb00057.x%3C%2Fa%3E	
Fonte: 	info:eu-repo/semantics/restrictedAccess