Data/hora: 05/06/2024 11:35:28

Provedor de dados: | 3
País: | Brazil
Título: | Effects of chronic exposure to hexavalent chromium in water on oxidative stress parameters in Wistar rats
Autores: | Machado, Aline Belem; Caprara, Juliana Foresti; Franceschi, Itiane Diehl de; Linden, Rafael; Berlese, Daiane Bolzan; Feksa, Luciane Rosa.
Data: | 2019-04-17
Ano: | 2019
Palavras-chave: | Bioquímica; Meio Ambiente; Contaminação metais pesados Antioxidant enzymes; Environmental contamination; Hexavalent chromium; Oxidative stress. Bioquímica.
Resumo: | Hexavalent chromium [Cr (VI)] is a metal utilized in different industries and consequently disposed in the environment. It is a toxic substance and its reduction to trivalent Cr [Cr (III)] generates intermediates, which are responsible for the oxidation of molecules, and cause the oxidative stress. Therefore, the aim of this study was to evaluate if Cr (VI) could induce oxidative stress in Wistar rats. In this study, Wistar rats were chronically exposed to 25 and 50 ppm of potassium dichromate in drinking water for 30 days. The levels of Cr were evaluated in the blood and tissues (liver, kidneys, and lungs). Oxidative stress was determined in the liver, kidneys, and lungs and was evaluated by DFCH, TBA-RS and carbonyl test. Antioxidant enzymes were evaluated through catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Regarding the results, Cr concentration was significantly elevated in all tissues, however, it was lower in the lungs. In relation to the oxidative stress parameters, there was a significant increase of DCFH levels in the kidneys and carbonyls in liver and kidneys. Regarding the antioxidant enzymes, SOD was decreased in all organs and GPx was diminished in the kidneys. These data indicated that Cr (VI) could induce oxidative stress in the kidneys and liver due to an imbalance between oxidative and antioxidant parameters. The lungs were little affected, possibly by the lowest chromium accumulation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771

10.4025/actascibiolsci.v41i1.43771

Editor: | Universidade Estadual De Maringá

Relação:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/pdf

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/19371

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/19372

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/19434

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/20201

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/21202

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43771/21203

Formato: | application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e43771

Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e43771

1807-863X

1679-9283

Fonte:

Direitos autorais 2019 Acta Scientiarum. Biological Sciences

http://creativecommons.org/licenses/by/4.0