Data/hora: 06/06/2024 02:44:29

Provedor de dados: 	3	
País: 	Brazil	
Título: 	Effect of pain related of sex and estrous cycle on blood plasma glucose, free fatty acids and corticosterone in rats - doi: 10.4025/actascibiolsci.v34i4.10568	
Autores: 	Moraes, Elzira Diniz de; Instituto de Ensino Superior de Londrina; Zaia, Cássia Thaís Bussamra Vieira; Universidade Estadual de Londrina; Zaia, Dimas Augusto Morozin; Universidade Estadual de Londrina; Santos, Angelo Alexander Torres dos; Universidade Estadual de Londrina; Ribeiro, Rachel Cezar de Andrade; Universidade Estadual de Londrina; Silva, Andreia Lopes da; Universidade Estadual de Londrina.	
Data: 	2012-09-04	
Ano: 	2012	
Palavras-chave: 	2.00.00.00-6 sex differences; Nociception; Stress; Hormones; Rats 2.07.00.00-8.	
Resumo: 	Sex differences related with pain have been studied and evidences suggesting influence of sex steroid hormones on the thresholds of pain. Experimental nociception has been test using formalin as a model of nociceptive stimulus. Association of stress, pain and metabolic and hormonal changes has not been explored. The aim of this study was to compare metabolic and hormonal changes between male rats and female rats in proestrus and estrus cycle after painful stimulus by formalin into the masseter muscle. Male and female Wistar rats (200-250 g b.w.) were submitted to an injection of formalin (F, 1.5%) or saline (S, 9.9%) into the masseter muscle and after 0 (N, control group without injection), 5, 15, 30 or 60 minutes they were decapitate and blood was collected to measure biochemical parameters. Plasma estradiol concentration (pg dL-1) was significantly higher in proestrus (106.3 ± 4.3, n = 45, p &amp;lt; 0.05) group compared to the estrous group (89.4 ± 3.5, n = 43). Blood plasma concentration of glucose (mg dL-1) was increased after 5 and 15 minutes of injection of formalin or saline in the animals, but in the estrus group the increase was bigger than in the others. Free fatty acids levels increased in the estrous group after 5, 15 and 30 minutes and also the corticosterone levels and these concentrations wer significantly different (p &amp;lt; 0.05) from either male or female animals in proestrus state. The results obtained suggesting that estradiol is related to a sensibility to pain and the estrus stage is related to stress and the estrous cycle has a modulator effect on pain and nociceptive sensibility.   	
Tipo: 	Estudos fisiológicos	
Idioma: 	Inglês	
Identificador: 	http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/10568

10.4025/actascibiolsci.v34i4.10568	
Editor: 	Universidade Estadual De Maringá	
Formato: 	application/pdf

application/pdf	
Fonte: 	Acta Scientiarum. Biological Sciences; v. 34, n. 4 (2012); 451-456

Acta Scientiarum. Biological Sciences; v. 34, n. 4 (2012); 451-456	
Fonte: 	DECLARATION OF ORIGINALITY AND CESSATION OF COPYRIGHTI Declare that current article is original and has not been submitted for publication, in part or in whole, to any other national or international journal. I also declare that once published in the Acta Scientiarum. Biological Sciences, a publication of the Universidade Estadual de Maringá, it will not be submitted by me or by any co-author to any other scientific communication mean. In my name and in the name of co-authors, I shall cede the copyright of the above mentioned article to the Universidade Estadual de Maringá and I declare that I know that the non-observance of this norm may make me liable for the penalties contemplated in the Law for the Protection of Authors’ Rights (Act 9609 of the 19th February 1998).

DECLARAÇÃO DE ORIGINALIDADE E CESSÃO DE DIREITOS AUTORAIS  Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Acta Scientiarum. Biological Sciences, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro meio de divulgação científica. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).