Data/hora: 01/06/2024 02:44:50

Provedor de dados: | 3
País: | Brazil
Título: | Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model
Autores: | Dalzochio, Thaís; Nienov, Otto Henrique; Wannmacher, Clovis; Berlese, Daiane Bolzan; Feksa, Luciane Rosa.
Data: | 2019-07-22
Ano: | 2019
Palavras-chave: | Animal model; Autoimmune disease; Enzymatic activity.
Resumo: | Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed in the liver and kidney of animals from diabetes and enterovirus groups. Under our experimental conditions, the ingestion of water experimentally contaminated by BEV induced alterations in glycaemia, and also interfered in the pyruvate kinase activity in liver and kidney of the rats, which might be one of the possible mechanisms involved in the T1D development.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765

10.4025/actascibiolsci.v41i1.43765

Editor: | Universidade Estadual De Maringá

Relação:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765/pdf

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43765/19359

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/downloadSuppFile/43765/19360

Formato: | application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e43765

Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e43765

1807-863X

1679-9283

Fonte:

Direitos autorais 2019 Acta Scientiarum. Biological Sciences

http://creativecommons.org/licenses/by/4.0