Data/hora: 01/06/2024 07:26:30

Provedor de dados: | 36
País: | Brazil
Título: | In vitro antioxidant, antitumor and leishmanicidal activity of riparin A, an analog of the Amazon alkamides from Aniba riparia (Lauraceae)
Autores: | ARAÚJO,Éverton José Ferreira de; LIMA,Layana Karine Farias; SILVA,Oskar Almeida; JÚNIOR,Luís Mário REZENDE; GUTIERREZ,Stanley Juan Chavez; CARVALHO,Fernando Aécio de Amorim; LIMA,Francisco das Chagas Alves; PESSOA,Cláudia; FREITAS,Rivelilson Mendes de; FERREIRA,Paulo Michel Pinheiro.
Data: | 2016-09-01
Ano: | 2016
Palavras-chave: | Bioprospecting; Chemoprevention; Cytotoxicity; Antiparasitic drug.
Resumo: | ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes of L. amazonensis (IC50 of 307.0 ± 79.6, 193.7 ± 44.3 and 81.8 ± 11.2 μg mL-1, respectively, after 24, 48 and 72 h of incubation). Then, in addition to its structural simplicity, riparin A revealed promising biological activities and remarkable in vitro leishmanicidal action, an important result in epidemiological point of view to control leishmaniasis in Brazil, including in the Amazon region.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000300309
Editor: | Instituto Nacional de Pesquisas da Amazônia
Relação: | 10.1590/1809-4392201505436
Formato: | text/html
Fonte: | Acta Amazonica  v.46 n.3 2016
Fonte: | info:eu-repo/semantics/openAccess