Data/hora: 06/06/2024 07:13:32

Provedor de dados: | 36
País: | Brazil
Título: | Evaluation of the antioxidant potential of Copaifera multijuga in Ehrlich tumor-bearing mice
Autores: | CUNHA,Ana Paula Simões da; BALDISSERA,Luana; PEREIRA,Débora Linsbinski; ALBIERO,Lucineia Reuse; CASTOLDI,Lindsey; SINHORIN,Adilson Paulo; SINHORIN,Valéria Dornelles Gindri.
Data: | 2019-03-01
Ano: | 2019
Palavras-chave: | Solid tumor; Oxidative stress; Free radicals; Copaiba; Antineoplasic.
Resumo: | ABSTRACT Copaifera multijuga, commonly known as copaiba, is popularly used in the form of tea for various conditions due to the presence of antioxidant substances in its composition, which protect cells against damage caused by free radicals. Its oleoresin is also used as an anti-inflammatory and antitumoral agent. The present study investigated the antioxidant effect of the ethanolic extract of copaiba stem bark on Swiss mice inoculated with solid Ehrlich tumors. Mice were inoculated subcutaneously with 1x106 Ehrlich’s tumor cells and treated via gavage with ethanolic extract of copaiba for thirty days, with doses varying between 100 and 200 mg kg-1. Biochemical analyses of enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST)], non-enzymatic antioxidants [reduced glutathione (GSH) and ascorbic acid (ASA)], substances reactive to thiobarbituric acid (TBARS) and protein carbonylation (carbonyl) in different tissues were significantly affected. The extract administered at 200 mg kg-1 presented higher antioxidant capacity in the liver, increased CAT, GST, GSH and decreased TBARS, as well as increased CAT activity and protein carbonylation in brain tissue. The results showed that the copaiba extract was able to reverse the oxidative stress caused by solid Ehrlich tumor, probably due to the presence of antioxidant compounds, and had potential antineoplasic effect after a 30-day treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000100041
Editor: | Instituto Nacional de Pesquisas da Amazônia
Relação: | 10.1590/1809-4392201800672
Formato: | text/html
Fonte: | Acta Amazonica  v.49 n.1 2019
Fonte: | info:eu-repo/semantics/openAccess