Data/hora: 02/06/2024 12:34:22

Provedor de dados: | 40
País: | Argentina
Título: | Anticoagulant and factor Xa-like activities of Tityus discrepans scorpion venom
Autores: | Brazón,Josmary; Guerrero,Belsy; Suze,D; Sevcik, Carlos,Gina; Arocha-Piñango,Carmen L.
Data: | 2013-06-01
Ano: | 2013
Palavras-chave: | Scorpion; Coagulation; Fibrinogen; Factor Xa.
Resumo: | Tityus discrepans venom (TdV) produces a variety of haemostatic manifestations including alveoli fbrin deposition and/ or prothrombin and partial thromboplastin time (PT, PTT) alterations in mammals. In vitro studies have demonstrated that TdV contains tissue plasminogen activator-like (t-PA), fbrinolytic and plasmin inhibitory compounds and produces platelets activation through GPVI and a novel Src-dependent signalling pathway. The aim of this study is to describe the initial characterization of procoagulant and anticoagulant components from TdV. This venom was fractionated by exclusion molecular chromatography on a Sephadex G-50 column. The eluted material was collected as fve fractions called S1 to S5. These fractions and the whole venom were used to evaluate factor Xa- and thrombin-like activities, fbrinogen degradation, furthermore thrombin- and factor Xa-inhibitory activities. The results demonstrated that TdV contain components with factor Xa-like activity (procoagulants) as well fbrinogenolytic compounds present in the fraction S1 and components with factor Xa inhibitory activity in the fractions S4 and S5 (anticoagulants).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432013000100003
Editor: | Asociación Toxicológica Argentina
Formato: | text/html
Fonte: | Acta toxicológica argentina  v.21 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess