Data/hora: 01/06/2024 09:51:34

Provedor de dados: | 42
País: | Brazil
Título: | Crude ethanol extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines
Autores: | Rennó,Magdalena N.; Barbosa,Gleyce M.; Zancan,Patricia; Veiga,Venicio F.; Alviano,Celuta S.; Sola-Penna,Mauro; Menezes,Fábio S.; Holandino,Carla.
Data: | 2008-09-01
Ano: | 2008
Palavras-chave: | Antitumoral agents; Ethanol extract; Orbignya speciosa.
Resumo: | Plant-derived substances have been considered as important sources of drugs, including antineoplasic agents. Babassu mesocarp is popularly used in Brazil as a food additive, and in popular medicine against several conditions, such as inflammations, menstrual pains and leukaemia. From babassu Orbignya speciosa (Mart.) Barb. Rodr. [Arecaceae (Palmae)] epicarp/mesocarp, an ethanol extract was prepared and named OSEME, which was tested on the viability,morphology and metabolism of several cell lines, such as the leukaemic cell lines, HL-60, K562 and the latter multidrug resistant counterpart K562-Lucena 1, the human breast cancer cell line MCF-7, the mouse fibroblast cell line 3T3-L1 and fresh human lymphocytes. OSEME promoted a dose-dependent decrease on the viability of all cells. This effect was much more pronounced on the tumoral cell lines than on non-tumoral cells, a phenomenon revealed by the dose of OSEME which promotes half of maximal effect (ID50). The decrease on viability was followed by shrinkage of cells, alteration on their morphology, and a markedly nuclear condensation. Curiously, stimulation of 6-phosphofructokinase activity (6.6-times) was observed on HL-60 cells, treated with OSEME, when compared to control treated with ethanol (vehicle). These results support evidences to suggest OSEME as a promising source of novel antineoplasic agents.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300008
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652008000300008
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.80 n.3 2008
Fonte: | info:eu-repo/semantics/openAccess