Data/hora: 13/06/2024 03:42:46

Provedor de dados: 	42	
País: 	Brazil	
Título: 	New enamine derivatives of lapachol and biological activity	
Autores: 	OLIVEIRA,MAILCAR F.; LEMOS,TELMA L.G.; MATTOS,MARCOS C. DE; SEGUNDO,TACIANA A.; SANTIAGO,GILVANDETE M.P.; BRAZ-FILHO,RAIMUNDO.	
Data: 	2002-06-01	
Ano: 	2002	
Palavras-chave: 	Lapachol; Enamine derivatives; Biological activities.	
Resumo: 	A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652002000200004	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.74 n.2 2002	
Fonte: 	info:eu-repo/semantics/openAccess