Data/hora: 10/06/2024 16:25:32

Provedor de dados: | 42
País: | Brazil
Título: | Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
Autores: | MONTE,ZENAIDE S.; SILVA,AMANDA M.; LIMA,GLÁUCIA M.S.; SILVA,TERESINHA G. DA; MARQUES,KARLA M.R.; RODRIGUES,MARIA D.; FALCÃO,EMERSON P.S.; MELO,SEBASTIÃO J.
Data: | 2017-06-01
Ano: | 2017
Palavras-chave: | Arylamidines; 2D spectroscopy; Gram-negative bacteria; Yeast; Cytotoxicity.
Resumo: | ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301051
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720160801
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.2 2017
Fonte: | info:eu-repo/semantics/openAccess