Data/hora: 06/06/2024 01:25:17

Provedor de dados: | 42
País: | Brazil
Título: | Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
Autores: | COSTA,RODRIGO M. DA; KARMIRIAN,KARINA; REHEN,STEVENS K.
Data: | 2018-08-01
Ano: | 2018
Palavras-chave: | Transmission electron microscopy; Mitochondria; Valproic acid; Epilepsy; Human neural progenitor cells; Electron tomography.
Resumo: | ABSTRACT Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders. Recently we showed changes in shape and membrane potential in mitochondria from human neural progenitor cells (NPCs) exposed to VPA (da Costa et al. 2015). Here, we applied transmission electron microscopy and electron tomography to evaluate mitochondrial damage caused by VPA in NPCs. Results showed mitochondrial cristae disorganization in a dose dependent manner. Disturbance in mitochondrial ultrastructure may influence metabolism, leading to synaptic plasticity and neurogenesis impairment. These data contribute to understanding VPA exposure potential effects on brain development.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502223
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201820170762
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.2 suppl.1 2018
Fonte: | info:eu-repo/semantics/openAccess