Data/hora: 14/06/2024 16:14:49

Provedor de dados: | 42
País: | Brazil
Título: | Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow
Autores: | LEMES,SUSY R.; CHAVES,DWIGHT A.; SILVA JÚNIOR,NELSON J. DA; CARNEIRO,CRISTIENE C.; CHEN-CHEN,LEE; ALMEIDA,LUCIANE M. DE; GONÇALVES,PABLO J.; MELO-REIS,PAULO R. DE.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Antigenotoxic; Carapa guianensis; Micronucleus; Oil.
Resumo: | ABSTRACT The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p &lt; 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct- and indirect-acting chemical mutagens, in a mammalian model.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502043
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720150797
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.3 suppl.0 2017
Fonte: | info:eu-repo/semantics/openAccess