Data/hora: 01/06/2024 01:27:56

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Atheroprotective action of a modified organoselenium compound:  in vitro evidence	
Autores: 	OLIVEIRA,JADE DE; STRALIOTTO,MARCOS R.; MANCINI,GIANNI; FIGUEIREDO,CLAUDIA P.; BRAGA,ANTÔNIO L.; TEIXEIRA,JOÃO B.R.; BEM,ANDREZA F.	
Data: 	2016-01-01	
Ano: 	2016	
Palavras-chave: 	Atherosclerosis; Compound HBD; Foam cell; GPx-like activity; LDL oxidation; Organoselenium compounds.	
Resumo: 	ABSTRACT Oxidation of low-density lipoprotein (LDL) has been strongly suggested to play a significant role in the pathogenesis of atherosclerosis. Thus, reducing LDL oxidation is a potential approach to decrease the risk of the atherosclerosis. Organoselenium compounds have demonstrated promising atheroprotective properties in experimental models. Herein, we tested the in vitro atheroprotective capability of a modified organoselenium compound, Compound HBD, in protecting isolated LDL from oxidation as well as foam cells formation. Moreover, the glutathione peroxidase (GPx)-like activity of Compound HBD was analyzed in order to explore the mechanisms related to the above-mentioned protective effects. The Compound HBD in a concentration-dependent manner reduced the Cu2+-induced formation of conjugated dienes. The protein portion from LDL were also protected from Cu2+-induced oxidation. Furthermore, the Compound HBD efficiently decreased the foam cell formation in J774 macrophage cells exposed to oxidized LDL. We found that the atheroprotective effects of this compound can be, at least in part, related to its GPx-like activity. Our findings demonstrated an impressive effect of Compound HBD against LDL-induced toxicity, a further in vivo study to investigate in more detail the antioxidant and antiatherogenic effects of this compound could be considered.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501953	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201620150760	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.88 n.3 suppl.0 2016	
Fonte: 	info:eu-repo/semantics/openAccess