Data/hora: 01/06/2024 06:13:09

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives	
Autores: 	SAÚDE-GUIMARÃES,DÊNIA A.; RASLAN,DÉLIO S.; CHIARI,EGLER; OLIVEIRA,ALAÍDE B. DE.	
Data: 	2014-12-01	
Ano: 	2014	
Palavras-chave: 	Eremantholide C derivatives; Lychnophora trichocarpha; NMR; Sesquiterpene lactones; Trypanocidal activity.	
Resumo: 	Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1′,2′- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1′,2′-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1′,2′-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401563	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201420140167	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.86 n.4 2014	
Fonte: 	info:eu-repo/semantics/openAccess