Data/hora: 06/06/2024 05:26:41

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats	
Autores: 	PINHEIRO,MARCELO S.; RODRIGUES,LUHARA S.; S. NETO,LEILA; MORAES-SOUZA,RAFAIANNE Q.; SOARES,THAIGRA S.; AMÉRICO,MADILEINE F.; CAMPOS,KLEBER E.; DAMASCENO,DÉBORA C.; VOLPATO,GUSTAVO T.	
Data: 	2017-03-01	
Ano: 	2017	
Palavras-chave: 	Bauhinia holophylla; Diabetes; Lipid profile; Medicinal plants; Rats.	
Resumo: 	ABSTRACT Bauhinia holophylla, commonly known as “cow’s hoof”, is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, the aim of this study was at evaluating the aqueous extract effect of Bauhinia holophylla leaves treatment on the streptozotocin-induced diabetic rats. Diabetes was induced by Streptozotocin (40 mg/Kg) in female Wistar rats. Oral administration of aqueous extract of Bauhinia holophylla leaves was given to non-diabetic and diabetic rats at a dose of 400 mg/kg during 21 days. On day 17 of treatment, the Oral Glucose Tolerance Test was performed to determine the area under the curve. At the end of the treatment, the animals were anesthetized and blood was collected for serum biochemical parameters analysis. After treatment with Bauhinia holophylla extract, non-diabetic and diabetic rats presented no glycemic changes. On the other hand, the plant treatment decreased body weight and increased ALT and AST activities. In conclusion, the treatment with aqueous extract of B. holophylla leaves given to diabetic rats presented no hypoglycemic effect in nondiabetic animals and no antidiabetic effect in diabetic animals with the doses studied. In addition, the diabetic animals treated with the B. holophylla extract showed inconvenient effects and its indiscriminate consumption requires particular carefulness.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100263	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720160050	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.1 2017	
Fonte: 	info:eu-repo/semantics/openAccess