Data/hora: 02/06/2024 08:38:06

Provedor de dados: | 42
País: | Brazil
Título: | Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
Autores: | EDUARDO-CANOSA,SILVINA; SIGÜEIRO,MARÍA MARCO, RITA; MOURIÑO,ANTONIO.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | D-ring modified vitamin D analogs; Aryl-Cr(CO)3 complexes; Cancer; Sigmatropic rearrangements; Synthesis.
Resumo: | ABSTRACT Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301035
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201820170701
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.90 n.1 suppl.2 2018
Fonte: | info:eu-repo/semantics/openAccess