Data/hora: 01/06/2024 07:29:08

Provedor de dados: | 42
País: | Brazil
Título: | A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus
Autores: | SANTOS,GABRIEL F. DOS; TAKAHASHI,JACQUELINE A.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Acetylcholinesterase inhibitors; Biotransformation; Green glycosylation; Mucor plumbeus; Trachyloban-19-oic acid.
Resumo: | ABSTRACT The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000501961
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720170240
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.3 suppl.0 2017
Fonte: | info:eu-repo/semantics/openAccess