Data/hora: 10/06/2024 05:45:19

Provedor de dados: | 42
País: | Brazil
Título: | Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
Autores: | Oliveira,Olga M.M.F.; Brunetti,Iguatemy L.; Khalil,Najeh M.
Data: | 2015-03-01
Ano: | 2015
Palavras-chave: | Nicotine; Myeloperoxidase; Hypochlorous acid; Low-density lipoprotein; Methyl linoleate; Vitamin E; Tryptophan.
Resumo: | In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201520140156
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.87 n.1 2015
Fonte: | info:eu-repo/semantics/openAccess