Data/hora: 01/06/2024 02:31:23

Provedor de dados: 	42	
País: 	Brazil	
Título: 	B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties	
Autores: 	Lopes,José Daniel; Mariano,Mario.	
Data: 	2009-09-01	
Ano: 	2009	
Palavras-chave: 	B-1 cells; IL-10; Inflammation; Infection; Neoplasia; BALB/Xid mice.	
Resumo: 	Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to present antigens to immunologically responsive cells and are endowed with regulatory properties. Further, we have also shown that these cells facilitate different types of infection as well as tumor growth and spreading. These data are presently reviewed pointing to a pivotal role that these cells may play in innate and acquired immunity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300013	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652009000300013	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.81 n.3 2009	
Fonte: 	info:eu-repo/semantics/openAccess