Data/hora: 02/06/2024 13:21:32

Provedor de dados: | 42
País: | Brazil
Título: | Oral insulin improves metabolic parameters in high fat diet fed rats
Autores: | LIPINSKI,LEANDRO C.; KMETIUK,LOUISE B.; MATHIAS,PAULO C.F.; MALTA,ANANDA; FAVERO,GIOVANI M.; RIBEIRO,TATIANE A.; TOLEDO,ALCEU; NETTO,MARIO R. MONTEMOR; RODRIGUES,MARCOS R.S.
Data: | 2017-09-01
Ano: | 2017
Palavras-chave: | Oral insulin; Intestine; Diabetes; Obesity; Metabolism; Pancreatic beta-cell.
Resumo: | ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS). Weight and food consumption were weekly obtained. After eight weeks, fasting blood samples were collected for laboratorial analysis. After euthanasia gut samples were isolated. Results: Rat oral insulin treatment decreased body weight gain (p&lt;0,001), fasting glucose and triglycerides serum levels (p&lt;0,05) an increased intestinal weight of distal ileum (P&lt;0,05). Animal submitted to high fat diet presented higher levels of HOMA-IR although significant difference to CT was not achieved. HOMA-beta were significantly higher (p&lt;0.05) in HFD+INS. Visceral fat was 10% lower in HFD+INS but the difference was not significant. Conclusions: In non-diabetic obese rats, oral insulin improves metabolic malfunction associated to rescue of beta-cell activity.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401699
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720170040
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.3 2017
Fonte: | info:eu-repo/semantics/openAccess