Data/hora: 01/06/2024 05:45:44

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats	
Autores: 	GAVRILOVIĆ,LJUBICA; STOJILJKOVIĆ,VESNA; KASAPOVIĆ,JELENA; POPOVIĆ,NATAŠA; PAJOVIĆ,SNEŽANA B.; DRONJAK,SLADJANA.	
Data: 	2013-09-01	
Ano: 	2013	
Palavras-chave: 	Adrenal medulla; Acute immobilization stress; Catecholamine; Chronic social isolation; Gene expression; Treadmill exercise.	
Resumo: 	ABSTRACTChronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks. Also, we examined how additional acute immobilization stress changes the mentioned parameters.Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chronically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma.Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000300999	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652013005000041	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.85 n.3 2013	
Fonte: 	info:eu-repo/semantics/openAccess