Data/hora: 05/06/2024 11:49:01

Provedor de dados: | 42
País: | Brazil
Título: | Caspase-3 activation and increased procollagen type I in irradiated hearts
Autores: | Ferreira-Machado,Samara C.; Salata,Camila; Rocha,Nazareth N.; Corrêa,Alexandre F.S.; Côrte-Real,Suzana; Peregrino,Antônio A.F.; Campos,Vera M.A. de; Andrade,Cherley B.V.; Bernardo-Filho,Mario; Cabral-Neto,Januário B.; Dealmeida,Carlos E.
Data: | 2013-03-01
Ano: | 2013
Palavras-chave: | Apoptosis; Caspase-3; Fibrosis; Heart; Ionizing radiation; TGF-β1.
Resumo: | The caspase-3-cleaved presence was evaluated in this study in the heart of irradiated rats, during the decline of ventricular function. Female Wistar rats were irradiated with a single dose of radiation (15 Gy) delivered directly to the heart and the molecular, histological and physiological evaluations were performed at thirteen months post-irradiation. The expressions of procollagen type I, TGF-ß1 and caspase-3-cleaved were analyzed using Western blotting. Cardiac structural and functional alterations were investigated by echocardiography and electron microscopy. In the irradiated group, the levels of procollagen type I, TGF-ß1 and caspase-3-cleaved are increased. Significant histological changes (degeneration of heart tissue and collagen deposition) and functional (reduced ejection fraction) were observed. Data suggest that the cardiac function decline after exposure to ionizing radiation is related, in part, to increased collagen and increased caspase-3-cleaved.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100215
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652013005000009
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.85 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess