Data/hora: 05/06/2024 01:24:13

Provedor de dados: | 42
País: | Brazil
Título: | Plasma miR-1273g-3p acts as a potential biomarker for early Breast Ductal Cancer diagnosis
Autores: | Guo,Huan; Zeng,Xiangting; Li,Haining; Guo,Yanxiang; Wang,Tao; Guo,Hongyun; Zhu,Gongjian; Wang,Lan; Zhou,Haihong; Liu,Kedan; Chen,Xiaoyi; Wang,Haitao; Zhao,Xinke; Su,Haixiang; Li,Yingdong.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Breast ductal carcinoma; Plasma; MiR-1273g-3p; Circulating miRNA; Biomarker.
Resumo: | Abstract  Circulating miRNAs presenting in plasma in a stable manner have been demonstrated their potential role as a promising biomarkers in many human diseases, such as Alzheimer’s disease, melanoma and ovarian carcinoma. However, few circulating miRNAs could be used for breast ductal cancer diagnosis. Here, we identified miR-1273g-3p as a biomarker for detecting breast ductal cancer. We detected miR-1273g-3p levels in the plasma of 39 sporadic breast ductal cancer patients and 40 healthy donors by Stem-loop Quantitative Real-time PCR (qRT-PCR). The results showed the plasma miR-1273g-3p level were significantly up-regulated in breast ductal cancer patients compared with healthy donors (p=0.0139). Receiver operating characteristic (ROC) curve also revealed the significantly diagnostic ability of miR-1273g-3p in patients (p=0.0414). In addition, the plasma level of miR-1273g-3p was closely related to IIIB-IIIC TNM stage. We also confirmed the higher expression level of miR-1273g-3p in breast cancer cell lines MCF-7 (4.872±0.537) than normal breast cells (Hs 578Bst). Taken together, miR-1273g-3p could represent as a potential biomarker for early breast ductal cancer diagnosis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100801
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765202020181203
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.92 n.1 2020
Fonte: | info:eu-repo/semantics/openAccess