Data/hora: 06/06/2024 05:34:59

Provedor de dados: 	42	
País: 	Brazil	
Título: 	6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression	
Autores: 	HOU,CHUN; MIAO,YONG; JI,HANG; WANG,SUSHENG; LIANG,GANG; ZHANG,ZHIHUA; HONG,WEIJIN.	
Data: 	2017-12-01	
Ano: 	2017	
Palavras-chave: 	MMP2; MMP9; 6-Gingerol; Hair growth.	
Resumo: 	ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602707	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720170354	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.4 2017	
Fonte: 	info:eu-repo/semantics/openAccess