Data/hora: 05/06/2024 03:30:36

Provedor de dados: | 42
País: | Brazil
Título: | Bacillus subtilis as a tool for vaccine development: from antigen factories to delivery vectors
Autores: | Ferreira,Luís C.S.; Ferreira,Rita C.C.; Schumann,Wolfgang.
Data: | 2005-03-01
Ano: | 2005
Palavras-chave: | Vaccines; Bacillus subtilis; Immunization; Protein expression.
Resumo: | Bacillus subtilis and some of its close relatives have a long history of industrial and biotechnological applications. Search for antigen expression systems based on recombinant B. subtilis strains sounds attractive both by the extensive genetic knowledge and the lack of an outer membrane, which simplify the secretion and purification of heterologous proteins. More recently, genetically modified B. subtilis spores have been described as indestructible delivery vehicles for vaccine antigens. Nonetheless both production and delivery of antigens by B. subtilis strains face some inherent obstacles, as unstable gene expression and reduced immunogenicity that, otherwise, can be overcome by already available gene technology approaches. In the present review we present the status of B. subtilis-based vaccine research, either as protein factories or delivery vectors, and discuss some alternatives for a better use of genetically modified strains.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000100009
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652005000100009
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.77 n.1 2005
Fonte: | info:eu-repo/semantics/openAccess