Data/hora: 15/06/2024 20:45:26

Provedor de dados: | 42
País: | Brazil
Título: | Neutrotoxic effects of fructose administration in rat brain: implications for fructosemia
Autores: | Macongonde,Ernesto A.; Costa,Naithan L.F.; Ferreira,Bruna K.; Biella,Mairis S.; Frederico,Marisa J.S.; Oliveira,Marcos R. de; Ávila Júnior,Silvio; Silva,Fátima R.M.B.; Ferreira,Gustavo C.; Streck,Emilio L.; Schuck,Patrícia F.
Data: | 2015-08-01
Ano: | 2015
Palavras-chave: | Brain damage; Fructose; Fructosemia; Hereditary fructose intolerance; Krebs cycle; Metabolism.
Resumo: | Fructose accumulates in tissue and body fluids of patients affected by hereditary fructose intolerance (HFI), a disorder caused by the deficiency of aldolase B. We investigated the effect of acute fructose administration on the biochemical profile and on the activities of the Krebs cycle enzymes in the cerebral cortex of young rats. Rats received a subcutaneous injection of NaCl (0.9 %; control group) or fructose solution (5 μmol/g; treated group). Twelve or 24 h after the administration, the animals were euthanized and the cerebral cortices were isolated. Peripheral blood (to obtain the serum) and cerebral spinal fluid (CSF) from the animals were also collected. It was observed that albumin levels were decreased and cholesterol levels were increased in CSF of animals 12 h after the administration of fructose. In addition, serum lactate levels were increased 12 h after the administration, as compared to control group. Furthermore, malate dehydrogenase activity was increased in cerebral cortex from treated group 24 h after the administration of this carbohydrate. Herein we demonstrate that fructose administration alters biochemical parameters in CSF and serum and bioenergetics parameters in the cerebral cortex. These findings indicate a possible role of fructose on brain alterations found in HFI patients.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301451
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201520140720
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.87 n.2 suppl.0 2015
Fonte: | info:eu-repo/semantics/openAccess