Data/hora: 11/06/2024 00:58:49

Provedor de dados: | 42
País: | Brazil
Título: | Schistosome serine protease inhibitors: parasite defense or homeostasis?
Autores: | Quezada,Landys A. Lopez; McKerrow,James H.
Data: | 2011-06-01
Ano: | 2011
Palavras-chave: | Schistosomiasis; Inhibitor; Protease; Serpin; Genome.
Resumo: | Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic analysis of two major serpin clades. S. mansoni shows a greater multiplicity of serpin genes, perhaps reflecting adaptation to infection of a human host. Putative targets of schistosome serpins can be predicted from the sequence of the reactive center loop (RCL). Schistosome serpins may play important roles in both post-translational regulation of schistosome-derived proteases, as well as parasite defense mechanisms against the action of host proteases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200025
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/S0001-37652011000200025
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.83 n.2 2011
Fonte: | info:eu-repo/semantics/openAccess