Data/hora: 09/06/2024 10:48:40

Provedor de dados: | 42
País: | Brazil
Título: | Antifibrotic effects of total or partial application of amniotic membrane in hepatic fibrosis
Autores: | MAMEDE,KARINA M.; SANT’ANNA,LUCIANA B.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Amniotic membrane; Histopathology; Immunohistochemistry; Liver fibrosis; Myofibroblasts.
Resumo: | Abstract: Liver fibrosis is the final common pathway of chronic liver diseases, having cirrhosis as a possible progression, which has liver transplantation as the only effective treatment. Human amniotic membrane represents a potential strategy as a therapy for liver fibrosis, due to its anti-inflammatory, anti-fibrotic and immunomodulatory properties. The aim of this study was to evaluate amniotic membrane effects as a treatment for hepatic fibrosis induced in rats by bile duct ligation (BDL), verifying alterations between two different forms of amniotic membrane application, around all the lobes of the liver and around only one lobe of the liver. Two weeks after inducing fibrosis, an amniotic membrane fragment was applied to the surface of the liver, covering it either totally or partially. Four weeks later, the animals were euthanized and liver samples were collected. Histopathological and quantitative analyses demonstrated fibrosis severity decrease and an extremely significant reduction in the deposition of collagen in the groups treated with amniotic membrane, particularly when the amniotic membrane was applied in only one liver lobe. It is concluded that the amniotic membrane acted on the repair of liver fibrosis in both modes of application, with the application of the amniotic membrane around only one hepatic lobe being more effective in reducing the severity / extent of fibrosis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500702
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201920190220
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.91 n.3 2019
Fonte: | info:eu-repo/semantics/openAccess