Data/hora: 09/06/2024 10:23:02

Provedor de dados: | 42
País: | Brazil
Título: | Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
Autores: | VICTOR,MAURICIO M.; DAVID,JORGE M.; SAKUKUMA,MARIA C.K.; COSTA-LOTUFO,LETÍCIA V.; MOURA,ANDREA F.; ARAÚJO,ANA J.
Data: | 2017-09-01
Ano: | 2017
Palavras-chave: | Antitumor activity; Chemical modification; Derivative synthesis; Natural products esters.
Resumo: | ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369
Editor: | Academia Brasileira de Ciências
Relação: | 10.1590/0001-3765201720160780
Formato: | text/html
Fonte: | Anais da Academia Brasileira de Ciências  v.89 n.3 2017
Fonte: | info:eu-repo/semantics/openAccess