Data/hora: 09/06/2024 15:57:08

Provedor de dados: 	42	
País: 	Brazil	
Título: 	Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity	
Autores: 	VICTOR,MAURICIO M.; DAVID,JORGE M.; SAKUKUMA,MARIA C.K.; COSTA-LOTUFO,LETÍCIA V.; MOURA,ANDREA F.; ARAÚJO,ANA J.	
Data: 	2017-09-01	
Ano: 	2017	
Palavras-chave: 	Antitumor activity; Chemical modification; Derivative synthesis; Natural products esters.	
Resumo: 	ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/0001-3765201720160780	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.89 n.3 2017	
Fonte: 	info:eu-repo/semantics/openAccess